Product Description

GNE Polyclonal Antibody

Catalogue Numbers: BS62530-50, BS62530-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y223

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:500~1:1000 IHC:1:50~1:200

Background: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GNE polyclonal antibody detects endogenous levels of GNE protein.

Extra Notes: Western blot (WB) analysis of GNE polyclonal antibody at 1:500 dilution
LaneA:L02 whole cell lysate
LaneB:The Liver tissue lysate of Mouse
LaneC:The Liver tissue lysate of Rat

Bioworld Molecular Weight: ~ 79 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: NM; DMRV; IBM2; Uae1; GLCNE

Immunogen: Synthetic peptide, corresponding to Human GNE.

Conjugate: Unconjugated

Modification: Unmodified