GNL3L Polyclonal Antibody-BS62387

GNL3L Polyclonal Antibody

Catalogue Numbers: BS62387-50, BS62387-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Swiss-Prot: Q9NVN8

Host: Rabbit

Reactivity: Human

Applications: WB, IHC

All Applications: WB:1:500~1:1000 IHC:1:50~1:200

Background: Guanine nucleotide-binding protein-like 3-like protein, stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

Purification and Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GNL3L polyclonal antibody detects endogenous levels of GNL3L protein.

Extra Notes: Western blot (WB) analysis of GNL3L polyclonal antibody at 1:500 dilution
LaneA:H1792 whole cell lysate
LaneB:MCF-7 whole cell lysate

Bioworld Molecular Weight: ~ 72 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Guanine nucleotide-binding protein-like 3-like protein; GNL3L

Immunogen: Synthetic peptide, corresponding to Human GNL3L.

Conjugate: Unconjugated

Modification: Unmodified