GnRH-R Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA25400-50, RA25400-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: gonadotropin releasing hormone receptor (GNRHR) Homo sapiens This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gen Reactivity: Human, Mouse Host: Rabbit Applications: WB, IF/ICC, ELISA Alternate Names: GNRHR, GRHR, Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. Molecular Weight: 37 Protein Molecular Weight (kDa): 37 Storage: -20°C/1 year Human Gene ID: 2798 Human SwissProt Number: P30968 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only