GnRH-R rabbit pAb - ES5571

GnRH-R rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5571-50, ES5571-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gen

Alternate Name: GNRHR; GRHR; Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R

Source: Rabbit

Applications: WB; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human GNRHR. AA range:41-90

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 37kD

Human Gene ID: 2798

Human SWISS Prot NO: P30968

Subcellular Location: Cell membrane; Multi-pass membrane protein.

Research Use Only