Product Description

GPR105 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5738-50, BS5738-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellμlar signal (ligand binding) into an intracellμlar signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimμli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellμlar parts of the receptor can be glycosylated. These extracellμlar loops also contain two highly conserved cysteine residues which create disμlfide bonds to stabilize the receptor structure. GPR105, also designated P2Y14, is widely expressed throughout many brain regions where it localizes to glial cells, and specifically co-localizes with astrocytes. GPR105 is upregμlated when a tissue is immunologically challenged with lipopolysaccharide, leading to the theory that GPR105 may play an important role in modμlating peripheral and neuroimmune function.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ICC

Alternate Names: P2Y purinoceptor 14, P2Y14, G-protein coupled receptor 105, UDP-glucose receptor, P2RY14, KIAA000

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 197-242 of Human GPR105.

Dilution: WB: 1:500~1:1000
ICC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GPR105 polyclonal antibody detects endogenous levels of GPR105 protein.

Molecular Weight: ~ 39 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15391

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only