Product Description

GPR119 (V227) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2606-50, BS2606-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellμlar signal (ligand binding) into an intra cellμlar signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimμli and mediate cell-cell communication. All of the receptors have seven membrane- spanning domains and the extracellμlar parts of the receptor can be glycosylated. These extracellμlar loops also contain two highly conserved cysteine residues which create disμlfide bonds to stabilize the receptor structure. GPR119 is a 335 amino acid protein that is mainly expressed in the pancreas. It is an endogenous receptor for lysophosphatidylcholine (LPC), which is is a lipid mediator involved in insμlin secretion from pancreatic  cells. GPR119 may participate in this insμlin secretion, suggesting that it may be potential target for new anti-diabetic drugs.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF

Alternate Names: Glucose-dependent insμlinotropic receptor, G-protein coupled receptor 119

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 190-240 of Human GPR119.

Dilution: IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GPR119 (V227) polyclonal antibody detects endogenous levels of GPR119 protein.

Molecular Weight: ~ 37 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8TDV5

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only