GPR143 rabbit pAb - ES6437

GPR143 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6437-50, ES6437-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009],

Alternate Name: GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein

Source: Rabbit

Applications: IF; ELISA

Dilution: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human GPR143. AA range:151-200

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 4935

Human SWISS Prot NO: P51810

Subcellular Location: Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673).

Research Use Only