Product Description

GPR18 Polyclonal Antibody

Catalogue Numbers: BS5744-50, BS5744-100

Sizes: 50µl, 100µl

Alternative Name: N-arachidonyl glycine receptor; NAGly receptor; G-protein coupled receptor 18; GPR18; GPCRW

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q14330

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB ICC

All Applications: WB: 1:500~1:1000
ICC: 1:50~1:200

Background: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR18 (G protein-coupled receptor 18), also known as GPCRW, is a 331 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor family. Expressed abundantly in spleen and testis, GPR18 functions as a receptor for N-arachidonyl glycine and is thought to contribute to the regulation of the immune system. GPR18 activity is mediated by G proteins that specifically inhibit adenylyl cyclase.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GPR18 polyclonal antibody detects endogenous levels of GPR18 protein.

Bioworld Molecular Weight: ~ 35 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of GPR18 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T cell lysate
Lane 2: sp2/0 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 239-284 of Human GPR18.

Conjugate: Unconjugated

Modification: Unmodified