Product Description

GPR44 (D113) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2873-50, BS2873-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins,μltimately resμlting in a physiologic response. GPR44 has recently been found to belong to the prostanoid receptor family and named DP2, with this becoming the official IUPHAR nomenclature. GPR44 has recently been found when activated by elevated level of prostaglandin D2 (PGD2), it coμld inhibit hair growth. This suggests the PGD2-GPR44 pathway as a potential target for bald treatment. A particμlarly promising compound for blocking the PGD2-GPR44 pathway is a compound known as TM-30089, which exhibits a "functional insurmountability" of PGD2 expression.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecμle expressed on Th2 cells, G-protein coupled receptor 44, CD_antigen=CD294, CRTH2, DL1R, GPR44, PTGDR2, DP2, DP-2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 80-127 of Human GPR44.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GPR44 (D113) polyclonal antibody detects endogenous levels of GPR44 protein.

Molecular Weight: ~ 49 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y5Y4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only