Granzyme B rabbit pAb - ES8917

Granzyme B rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8917-50, ES8917-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016],

Alternate Name: Granzyme B (EC 3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E)

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human Granzyme B Polyclonal AA range: 81-130

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 38kD

Human Gene ID: 3002

Human SWISS Prot NO: P10144

Subcellular Location: Secreted. Cytolytic granule. Delivered into the target cell by perforin (PubMed:20038786).

Research Use Only