Product Description

GREM1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-14111-60, E-AB-14111-120, E-AB-14111-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: GREM1

Target Synonym: BMP antagonist 1; Cell proliferation inducing gene 2 protein; Cell proliferation-inducing gene 2 protein; CKTSF1B1; colorectal adenoma and carcinoma 1; Cysteine knot superfamily 1; Cysteine knot superfamily 1; BMP antagonist 1; Cysteine knot superfamily BMP antagonist 1; DAN domain family member 2; DAND2; Down regulated in Mos-transformed cells protein; Down-regulated in Mos-transformed cells protein; DRM; grem1; GREM1; Gremlin 1 homolog; cysteine knot superfamily; Gremlin 1 like protein; Gremlin 1; cysteine knot superfamily; homolog; GREMLIN; Gremlin-1; Gremlin1; IHG-2; IHG2; Increased in high glucose 2; Increased in high glucose protein 2; PIG2; Proliferation inducing gene 2; proliferation inducing gene 2 protein

Research Areas: Signal Transduction, Stem Cells

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: O60565

Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Concentration: 0.3 mg/mL

Immunogen: Recombinant protein of human GREM1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 21kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only