GRID2 Polyclonal Antibody - E-AB-92148

GRID2 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-92148-60, E-AB-92148-120, E-AB-92148-200 Citations, Manuals and MSDS Available upon request. Abbreviation: GRID2 Target Synonym: GluD2; SCAR18; GRID2 Research Areas: Neuroscience Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Mouse, Rat Application: WB, IF Isotype: IgG Clonality: Polyclonal UNIProt ID: O43424 Background: The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014] Concentration: 1mg/mL Immunogen: A synthetic peptide of human GRID2 Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3. Purification Method: Affinity purification Dilution: WB 1:500-1:2000, IF 1:50-1:200 Observed MW: 113KDa Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only