GRK2 (Phospho-Tyr86) rabbit pAb - ES15903

GRK2 (Phospho-Tyr86) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES15903-50, ES15903-100

Citations, Manuals and MSDS Available upon request.

Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],

Alternate Name: Beta-adrenergic receptor kinase 1 (Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2)

Source: Rabbit

Applications: IHC; IF; WB

Dilution: IHC-p 1:50-200, WB 1:500-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human GRK2 (Phospho-Tyr86)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 75kD

Human Gene ID: 156

Human SWISS Prot NO: P25098

Subcellular Location: Cytoplasm. Cell membrane. Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse.

Research Use Only