GRM1 Polyclonal Antibody
Catalogue Numbers: BS60765-50, BS60765-100
Sizes: 50µl, 100µl
Alternative Name: Metabotropic glutamate receptor 1; mGluR1; GRM1; GPRC1A; MGLUR1
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q13255
Host: Rabbit
Reactivity: Human
Applications: WB
All Applications: WB: 1:500~1:1000
Background: The mGluR proteins (metabotropic glutamate receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-1, which can form a homodimer acts as a receptor for glutamate. It may also be involved in glutamate activity in the CNS.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GRM1 polyclonal antibody detects endogenous levels of GRM1 protein.
Bioworld Molecular Weight: ~ 132 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of GRM1 polyclonal antibody at 1:500 dilution
Lane 1: A549 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human GRM1
Conjugate: Unconjugated
Modification: Unmodified