Product Description

GRTP1 Polyclonal Antibody

Catalogue Numbers: BS62384-50, BS62384-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Swiss-Prot: Q5TC63

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB, IHC

All Applications: WB:1:500~1:1000 IHC:1:50~1:200

Background: Pituitary growth hormone (GH), also designated somatotropin, plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membranebound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GRTP1 (growth hormoneregulated TBC protein 1), also designated TBC1 domain family member 6, is a 336 amino acid protein with expression modulated by growth hormone. The TBC1 domain of GRTP1 is a region that is notably conserved among GTPaseactivating proteins, which characteristically play a role in the cell cycle and mitosis coordination. Interestingly, expression of GRTP1 is significantly upregulated in post-puberty testis and then maintained in the adult, suggesting that the germ cell may be the major site of GRTP1 function. There are two isoforms of GRTP1, which are a result of alternative splicing events.

Purification and Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GRTP1 polyclonal antibody detects endogenous levels of GRTP1 protein.

Extra Notes: Western blot (WB) analysis of GRTP1 polyclonal antibody at 1:500 dilution
LaneA:A549 whole cell lysate
LaneB:Jurkat whole cell lysate
LaneC:THP-1 whole cell lysate
LaneD:PC12 whole cell lysate
LaneE:Raw whole cell lysate

Bioworld Molecular Weight: ~ 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Growth hormone-regulated TBC protein 1; TBC1 domain family member 6; GRTP1; TBC1D6

Immunogen: Synthetic peptide, corresponding to Human GRTP1.

Conjugate: Unconjugated

Modification: Unmodified