Product Description

GSHB Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11903-50, ES11903-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: GSHB,

Specificity: GSHB Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Brain, Fetal brain cortex, Kidney, Lung,

Observed Band (KD): 52kD

Fields: Cysteine and methionine metabolism, Glutathione metabolism, Metabolic pathways, Biosynthesis of cofactors, Ferroptosis

Function: Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. Disease: Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency) [MIM:266130]; referred to as 5-oxoprolinuria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. Disease: Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes [MIM:231900]. It is a mild form causing hemolytic anemia. pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. Similarity: Belongs to the eukaryotic GSH synthase family. Subunit: Homodimer.

Subcellular Location: cytosol, extracellular exosome,

Storage and Stability: -20°C/1 year

Gene Name: GSS

Protein Name: Glutathione synthetase, GSH synthetase, GSH-S, EC 6.3.2.3, Glutathione synthase

Human Gene ID: 2937

Human SwissProt Number: P48637

Mouse SwissProt Number: P51855

Rat SwissProt Number: P46413

Research Use Only