Product Description

GSK3α/β (G273) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1412-50, BS1412-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regμlatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insμlin stimμlates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimμlation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubμle dynamics and cell motility.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Glycogen synthase kinase-3 alpha, GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 beta, GSK-3 beta, GSK3B

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human GSK3α.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GSK3α/β (G273) polyclonal antibody detects endogenous levels of GSK3α/β protein.

Molecular Weight: ~ 46, 51 kDa

Pathway: PI3K AKT signaling, Hedgehog Signaling, Hypoxia Signaling, Translational Contral elF4 and p70 S6 Kinase, Translational Contral Regμlation of elF2, Regμlation of Microtubμle Dynamics, Inhibition of Apoptosis, Insμlin &Glucose Signaling, Cell Cycle Control G1 S Checkpoint, Adherens Junction signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49840/P49841

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only