Product Description

GSK3β (S13) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1157-50, BS1157-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regμlates glycogen synthesis in response to insμlin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regμlation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regμlate cyclin D1 proteolysis and subcellμlar localization.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IF, IP

Alternate Names: Glycogen synthase kinase-3 beta, GSK-3 beta, Serine/threonine-protein kinase GSK3B

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to Human GSK3β.

Dilution: WB: 1:500~1:1000
IF: 1:50~200
IP: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GSK3β (S13) polyclonal antibody detects endogenous levels of GSK3β protein.

Molecular Weight: ~ 46 kDa

Pathway: PI3K AKT signaling, Hedgehog Signaling, Hypoxia Signaling, Translational Contral Regμlation of elF2, Regμlation of Microtubμle Dynamics, Inhibition of Apoptosis, Insμlin &Glucose Signaling, Cell Cycle Control G1 S Checkpoint, Adherens Junction signaling, MTOR signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49841

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only