Product Description

GSK3 beta Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66643-50, MB66643-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regμlates glycogen synthesis in response to insμlin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regμlation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regμlate cyclin D1 proteolysis and subcellμlar localization.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: WB, IHC, FC

Alternate Names: Glycogen synthase kinase-3 beta, GSK-3 beta, Serine/threonine-protein kinase GSK3B

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant fragment of human GSK3B (AA: 2-159) expressed in E. Coli.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/100), FC (1/50 - 1/100)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of GSK3 beta protein.

Molecular Weight: ~ 46 kDa

Pathway: Adherens Junction signaling, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer\'s Disease, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Cell Cycle Control G1 S Checkpoin, MAPK Erk in Growth and Differentiation Pathway, Hedgehog Signaling, Inhibition of Apoptosis, Insμlin &Glucose Signaling, Regμlation of Microtubμle Dynamics, NF-kB Signaling, PI3K AKT signaling, Translational Contral Regμlation of elF2, Translational Contral elF4 and p70 S6 Kinase, Wntβ catenin signaling, MTOR signaling.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49841

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only