Product Description

GSK3 beta (Phospho-S9) Rabbit Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66301-50, MB66301-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regμlates glycogen synthesis in response to insμlin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regμlation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus,  and mammalian development. GSK-3 has been shown to regμlate cyclin D1 proteolysis and subcellμlar localization.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: Glycogen synthase kinase-3 beta, GSK-3 beta, Serine/threonine-protein kinase GSK3B

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser9 of human GSK3 beta

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/100), IF/ICC (1/50 - 1/100)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of GSK3 beta (pS9) protein.

Molecular Weight: ~ 46 kDa

Pathway: Adherens Junction signaling, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer\'s Disease, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Translational Contral elF4 and p70 S6 Kinase, Translational Contral Regμlation of elF2, Receptors Signaling to MAPK Erk, Regμlation of Microtubμle Dynamics, Hedgehog Signaling, Inhibition of Apoptosis, Insμlin &Glucose Signaling, NF-kB Signaling, PI3K AKT signaling, Wntβ catenin signaling, MTOR signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49841

Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Research Use Only