Product Description

GUSB Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61590-50, BS61590-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The enzyme β-glucuronidase catalyzes the conversion of β-D-glucuronoside and water to an alcohol and D-glucuronate. Deficiency of β-glucuronidase is the cause of the human lysosomal storage disorder mucopolysaccharidosis type VII (MPS VII). Specifically, two residues appear important for catalytic activity: Glu 451 and Glu 540. Mutations at these sites affect the overall structure of the protein, which normally consists of a homotetramer with each promoter including a jelly roll barrel, an immunoglobμlin constant domain and a TIM barrel. Regμlation of β-glucuronidase activity may play a role in tumorigenesis and the invasiveness of a number of cancers, and is also an important factor in the development of functional prodrugs that require the cleavage of an active cytostatic by endogenous enzymes for antitumor activity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: asd, Beta G1, Beta glucuronidase, Beta-G1, Beta-glucuronidase, BG, BGLR, BGLR_HUMAN, FLJ39445, Glucuronidase beta, Gur, Gus, Gus-r, Gus-s, Gus-t, Gus-u, GUSB, Gut, MPS7

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 324-368 of Human GUSB.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Specificity: GUSB polyclonal antibody detects endogenous levels of GUSB protein.

Molecular Weight: ~ 74 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08236

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only