Product Description

GYS1 (phospho-S641) Rabbit Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS9838M-50, BS9838M-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P13807

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC IHC

All Applications: WB: 1:1000-1:2000
ICC: 1:50-1:200
IHC: 1:50-1:200

Background: Glycogen [starch] synthase belongs to the mammalian/fungal glycogen synthase family of proteins. Two forms of this protein exist, a liver form and a muscle form, both of which have the same function in the glycogen biosynthesis pathway. Glycogen synthase transfers the glycosyl residue from UDP-Glucose to the nonreducing end of a-1,4-glucan. The liver glycogen synthase protein is truncated by 34 amino acids compared to the muscle form. However, these enzymes differ significantly in their amino- and carboxyl-terminal regions. Muscle glycogen synthase serves to fuel muscular activity only and is regulated by muscle contraction and by catecholamines. Liver glycogen synthase mediates blood glucose homeostasis in response to nutritional cues. Defects in the gene encoding liver glycogen synthase results in glycogen storage disease type 0 (GSD0), a rare form of fasting ketotic hypoglycemia.

Purification and Purity: Protein A affinity purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of human GYS1 protein only when phosphorylated at Ser641.

Bioworld Molecular Weight: ~ 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of GYS1 (phospho-S641) Rabbit mAb at 1:1000 dilution
Lane 1: Mouse liver lysate, untreated
Lane 2: Mouse liver lysate, treated with AP, Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-Phospho-Glycogen synthase 1(S641) antibody. Counter stained with hematoxylin., ICC staining Phospho-Glycogen synthase 1(S641) in A549 cells (green). The nuclear counter stain is DAPI (blue).Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100/PBS.

Alternative Name: Glycogen [starch] synthase, muscle (EC:2.4.1.11); GYS1; GYS

Immunogen: Recombinant antibody.

Conjugate: Unconjugated

Modification: Phosphorylation