Product Description

GZMA Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7978-50, BS7978-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granμles and released by effector cells during degranμlation. In activated CTLs, granzyme A and granzyme B are processed and activated by cathepsin C, and they then function to induce apoptosis by two distinct pathways. Granzyme B proteolytically cleaves and activates members of the caspase family of cysteine proteases, including caspase-3, caspase-6, caspase-7 and caspase-9. When cleaved, these caspases assemble into active holoenzymes that then mediate apoptosis through a defined proteolytic cascade involving nuclear lamins and PARP (poly (ADP ribose) polymerase). Granzyme A mediates the activation of apoptosis by inducing single-strand DNA breaks, membrane perturbation and nuclear condensations in an alternative pathway that is independent from caspase activation or the caspase proteolytic cascade.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF

Alternate Names: CTL tryptase, CTLA3, Cytolytic t cell and natural killer cell specific trypsin like serine protease, Cytotoxic T lymphocyte associated serine esterase 3, Cytotoxic T lymphocyte proteinase 1, Cytotoxic T-lymphocyte proteinase 1, Fragmentin 1, Fragmentin-1, GRAA_HUMAN, Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3, Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3, Hanukah factor serine protease), Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3), Granzyme A, Granzyme A precursor, Granzyme-1, GZMA, H factor, Hanukah factor serine protease, Hanukkah factor, HF, HFSP, TSP1,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human GZMA.

Dilution: WB 1:500 - 1:2000
IF 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GZMA polyclonal antibody detects endogenous levels of GZMA protein.

Molecular Weight: ~ 35 kDa

Pathway: Immune checkpoint signaling in the Tumor Microenvironment,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P12544

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only