HABP2 Polyclonal Antibody
Catalogue Numbers: BS60689-50, BS60689-100
Sizes: 50µl, 100µl
Alternative Name: Hyaluronan-binding protein 2; Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein; HABP2; HGFAL; PHBP
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q14520
Host: Rabbit
Reactivity: Human, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: The hyaluronan-binding protein 2 (HABP2), also designated plasma hyaluronan-binding protein (PHBP) or factor VII-activating protease, belongs to the peptidase S1 family and contains three EGF-like domains, one kringle domain and one peptidase S1 domain. HABP2 is a heterodimer that contains a heavy chain of 50 kDa and a light chain of 27 kDa, which are linked by a disulfide bond. HABP2 is ubiquitously expressed and acts as a serine protease with fibrinogen and fibronectin being the major substrates. HABP2 has been shown to cleave the alpha-chain at multiple sites and the beta-chain between lysine53 and lysine54, but not the gamma-chain of fibrinogen. Overexpression of HABP2 has been shown to occur in lung adenocarcinomas and may be a useful biomarker for that type of cancer.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: HABP2 polyclonal antibody detects endogenous levels of HABP2 protein.
Bioworld Molecular Weight: ~ 63 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of HABP2 polyclonal antibody at 1:500 dilution
Lane 1: Hela whole cell lysate
Lane 2: PC12 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human HABP2
Conjugate: Unconjugated
Modification: Unmodified