HAS2 Monoclonal Antibody Catalogue Numbers: MB67169-50, MB67169-100 Sizes: 50µl, 100µl Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Swiss-Prot: Q92819 Host: Mouse Reactivity: Human Applications: WB All Applications: WB (1/500 - 1/4000) Background: HAS1, HAS2 and HAS3 are HA synthase proteins that synthesize HA (hyaluronan or hyaluronic acid). The extracellular matrix in most vertebrates expres HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 andβ-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesise high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli suggesting distinct functional roles of the three proteins. HAS2 mRNA shows predominant expression in chondrocytes and cartilage. The human HAS2 gene maps to chromosome 8q24.13 Purification and Purity: This antibody is purified through a protein G column. Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: Recognizes endogenous levels of HAS2 protein. Extra Notes: Western blot analysis of HAS2 expression in SW620 (A) whole cell lysates. Bioworld Molecular Weight: ~ 68 kDa Note: For research use only, not for use in diagnostic procedure. Alternative Name: Hyaluronan synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2 Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HAS2. The exact sequence is proprietary. Conjugate: Unconjugated Modification: Unmodified