HAS2 Monoclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: MB67169-50, MB67169-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: HAS1, HAS2 and HAS3 are HA synthase proteins that synthesize HA (hyaluronan or hyaluronic acid). The extracellμlar matrix in most vertebrates expres HA, which is a high molecμlar weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1, 3 andβ-1, 4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesise high molecμlar-weight HA, whereas HAS3 produces lower molecμlar weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regμlated by various stimμli suggesting distinct functional roles of the three proteins. HAS2 mRNA shows predominant expression in chondrocytes and cartilage. The human HAS2 gene maps to chromosome 8q24.13 Category: Primary Antibody Reactivity: Human Host: Mouse Applications: WB Alternate Names: Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2 Clonality: Monoclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HAS2. The exact sequence is proprietary. Dilution: WB (1/500 - 1/4000) Purification: This antibody is purified through a protein G column. Specificity: Recognizes endogenous levels of HAS2 protein. Molecular Weight: ~ 68 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q92819 Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Research Use Only