HBEGF rabbit pAb - ES11256

HBEGF rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES11256-50, ES11256-100

Citations, Manuals and MSDS Available upon request.

Background: function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor., PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937)., PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active., similarity:Contains 1 EGF-like domain., subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Rat; Mouse

Immunogen: Synthesized peptide derived from human protein . at AA range: 130-210

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 22kD

Human Gene ID: 1839

Human SWISS Prot NO: Q99075

Subcellular Location: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.

Research Use Only