Product Description

HC-II (D68) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS9125-50, BS9125-100

Sizes: 50µl, 100µl

Swiss-Prot: P05546

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

Background: Heparin cofactor II (HCII) is a glycoprotein in human plasma which rapidly inactivates Thrombin in the presence of dermatan sulfate. Inhibition occurs by formation of a stable equimolar complex between HCII and Thrombin. Certain clinical conditions, such as hepatic failure, disseminated intravascular coagulation, thalasemina and sickle cell anemia, display reduced levels of HCII. However, during pregnancy, physiological levels of HCII expression are elevated. HCII may regulate coagulation and may participate in processes such as inflammation, atherosclerosis and wound repair. HCII is widely distributed among vertebrates and may have a common function in birds, amphibians and mammals.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: HC-II (D68) polyclonal antibody detects endogenous levels of HC-II protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of HC-II (D68) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 57 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Heparin cofactor 2; Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1; SERPIND1; HCF2

Immunogen: Synthetic peptide, corresponding to amino acids 41-90 of Human HC-II.

Conjugate: Unconjugated

Modification: Unmodified