Product Description

HCCA2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60058-50, BS60058-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HCCA2 (Hepatocellμlar carcinoma-associated gene 2), also known as MOB2 (Mps one binder kinase activator-like 2), is a 467 amino acid protein that belongs to the MOB1/phocein family. HCCA2 is expressed in lung, spleen, brain, and fetal liver. It is highly expressed in hepatocellμlar carcinoma. HCCA2 is localized in the perinuclear region of the cytoplasm in liver cancer tissues and colocalizes with MAD2L2 in the nucleus of Hela cells. HCCA2 is chracaterized by two N-glycosylation sites, six N-myristolylation sites, two Src homolgy 3 (SH3), and several phosphorylation motifs which indicate that this protein may play a role in an intracellμlar signal transduction cascade. HCCA2 binds to and regμlates the autophosphorylation of the related human serine/threonine kinase 38 (NDR1) and serine/threonine kinase 38L (NDR2). It has been shown that HCCA2 plays a critical role in cell cycle regμlation. Overexpression of the protein during the G0/G1 phase inhibits cell proliferation causing cell cycle arrest.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: MOB kinase activator 2, Mob2 homolog, Mps one binder kinase activator-like 2, MOB2, HCCA2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human HCCA2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: HCCA2 polyclonal antibody detects endogenous levels of HCCA2 protein.

Molecular Weight: ~ 28 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q70IA6

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only