Product Description

HDAC1 Monoclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-22208-60, E-AB-22208-120, E-AB-22208-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: HDAC1 Mouse (4E1)

Target Synonym: DKFZp686H12203; GON 10; HD1; HDAC 1; HDAC1; HDAC1; Histone deacetylase 1; Reduced potassium dependency yeast homolog like 1; RPD3; RPD3L1

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells

Conjugation: Unconjugated

Host: Mouse

Species Reactivity: Human, Mouse, Rat

Application: IHC-p

Isotype: IgG

Clonality: Monoclonal

Clone No.: Clone:4E1

UNIProt ID: Q13547

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.

Concentration: 1 mg/mL

Immunogen: Synthetic Peptide of HDAC1

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification Method: Protein A purification

Dilution: IHC 1:100-200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only