Product Description

HDAC10 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90616-50, BS90616-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q969S8(Human) Q6P3E7(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC IP,

All Applications: WB:1:1,000
ICC:1:50-1:200

Background: Histone deacetylases (HDACs) play an important role in the modification of chromatin structure and thus in the suppression and activation of transcription and cellular differentiation. There are 11 members in the HDAC family that are divided into four classes. Class I HDACs represent homologs of the yeast histone deacetylase Rpd3, class II HDACs share strong homology with the yeast histone deacetylase Hda1, class III HDACs are closely related to the yeast Sir2 protein and class IV HDACs comprise histone deacetylase 11 (HDAC11)-related enzymes. HDAC10, also known as HD10, is a member of the class II HDACs. It contains an N-terminal Hda1p-related catalytic domain and a unique C-terminal leucine-rich domain. HDAC10 is ubiquitously expressed and can shuttle between the cytoplasm and nucleus in response to celllular signals. It is able to repress transcription and, like other class II HDAC members, its enzymatic activity is inhibited by Trichostatin A (TSA).

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: HDAC10 polyclonal antibody detects endogenous levels of HDAC10 protein.

Bioworld Molecular Weight: 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of HDAC10 on HepG2 cells lysates using anti-HDAC10 antibody at 1/1,000 dilution., ICC staining HDAC10 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: HD10, DKFZP761B039, HD 10, HD10, HDA10, HDAC 10, Hdac10, Histone deacetylase 10, MGC149722, OTTHUMP00000028555,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified