Product Description

HDAC2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-31644-60, E-AB-31644-120, E-AB-31644-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: HDAC2

Target Synonym: D10Wsu179e; HD 2; HD2; HDAC 2; Hdac2; HDAC2; Histone deacetylase 2 (HD2); Histone deacetylase 2; OTTHUMP00000017046; OTTHUMP00000227077; OTTHUMP00000227078; RPD3; transcriptional regulator homolog RPD3; YAF1; YY1 associated factor 1; YY1 transcription factor binding protein; Yy1bp

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat, Monkey

Application: WB, IHC-p, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q92769

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity.

Concentration: 1 mg/mL

Immunogen: Synthesized peptide derived from human HDAC2 around the non-phosphorylation site of Ser394.

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000

Calculated MW: 55kDa

Observed MW: 55kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only