Product Description

HDAC6 (3B2) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3031-50, MB3031-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q9UBN7

Host: Mouse

Reactivity: Human, Rat

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of HDAC6 in T47D, Jurkat CHO-K1 and CHO-K1 transfected by HDAC6fragment EGFP fusion proteinLysates using HDAC6 antibody.

Bioworld Molecular Weight: Calculated MW: 131 kDa; Observed MW: 160 kDa

Specificity: IgG2a

Alternative Name: HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6

Immunogen: Purified recombinant human HDAC6 protein expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified