HDAC7 (phospho Ser155) rabbit pAb - ES6538

HDAC7 (phospho Ser155) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6538-50, ES6538-100

Citations, Manuals and MSDS Available upon request.

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Alternate Name: HDAC7; HDAC7A; Histone deacetylase 7; HD7; Histone deacetylase 7A; HD7a

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human HDAC7A around the phosphorylation site of Ser155. AA range:121-170

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 103kD

Human Gene ID: 51564

Human SWISS Prot NO: Q8WUI4

Subcellular Location: Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

Research Use Only