HDAC8 rabbit pAb - ES2506

HDAC8 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2506-50, ES2506-100

Citations, Manuals and MSDS Available upon request.

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],

Alternate Name: HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human HDAC8. AA range:5-54

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 42kD

Human Gene ID: 55869

Human SWISS Prot NO: Q9BY41

Subcellular Location: Nucleus. Chromosome. Cytoplasm. Excluded from the nucleoli (PubMed:10748112). Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051).

Research Use Only