Product Description

HECW1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32616-50, RA32616-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS., pathway:Protein modification; protein ubiquitination., similarity:Contains 1 C2 domain., similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain., similarity:Contains 2 WW domains., subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1., tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 176

Protein Molecular Weight (kDa): 176

Storage: -20°C/1 year

Human Gene ID: 23072

Human SwissProt Number: Q76N89

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only