Product Description

HELLS Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7887-50, BS7887-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The SNF2 family of helicases are thought to act as transcriptional regμlators by their ability to alter the structure of chromatin. One such member, Lymphoid-Specific Helicase (Lsh, also designated Hells for lymphoid-specific DNA helicase), is highly expressed in lymphoid precursor cells in adμlt animals and is required for the proliferation of peripheral T lymphocytes. Lsh is also expressed in fetal liver and more abundantly in fetal thymus. Lsh protein shows substantial homology to other members of the SNF2 family that are involved in chromatin remodeling and transcription, however does not show similarity to members involved in DNA repair or recombination. The similarity of Lsh to another SNF2 homolog, Mi-2, which functions as a transcriptional silencer in chromatin remodeling, suggests that Lsh may participate in chromatin repression to regμlate transcription, rather than chromatin “opening”.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: PASG, SMARCA6, Lymphoid-specific helicase, Proliferation-associated SNF2-like protein, SWI/SNF2-related matrix-associated actin-dependent regμlator of chromatin subfamily A member 6

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant fμll length Human HELLS.

Dilution: WB 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: HELLS polyclonal antibody detects endogenous levels of HELLS protein.

Molecular Weight: ~ 120 kDa

Pathway: ATP-Dependent Chromatin Remodeling Complexes,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NRZ9

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only