HER2/ErbB2 (phospho-Tyr1196) Rabbit Polyclonal Antibody - RA25684

HER2/ErbB2 (phospho-Tyr1196) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA25684-50, RA25684-100

Citations, Manuals and MSDS Available upon request.

Background: erb-b2 receptor tyrosine kinase 2 (ERBB2) Homo sapiens This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:1000-2000

Alternative Names: Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)

Applications: WB

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 2064

Protein MW (KDa): 180

SWISS: P04626

Source: Rabbit

Research Use Only