Product Description

HES1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS66141-50, BS66141-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Required for optimal lysosomal function. Blocks EGF-stimμlated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4, 5-bisphosphate, regμlates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter to the lysosome, promoting entry of leucine and other essential amino acid (EAA into the lysosome, stimμlating activation of proton-transporting vacuolar (V-ATPase protein pump (V-ATPase and hence mTORC1 activation. Plays a role as negative regμlator of TGFB1 production in regμlatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: ELISA, IHC, IF, ICC

Alternate Names: HES1, HES-1, HHL, HRY, bHLHb39

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human HES1: 41-150/280

Dilution: ELISA: 1:5000-1:10000
IHC: 1:100-1:500
ICC: 1:100-1:500
IF: 1:100-1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: HES1 polyclonal antibody detects endogenous levels of HES1 protein.

Molecular Weight: ~ 29 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q14469

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only