Product Description

Hexb Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA25689-50, RA25689-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: hexosaminidase subunit beta (HEXB) Homo sapiens Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC-p, IF/ICC, ELISA

Alternate Names: HEXB, HCC7, Beta-hexosaminidase subunit beta, Beta-N-acetylhexosaminidase subunit beta, Hexosaminidase subunit B, Cervical cancer proto-oncogene 7 protein, HCC-7, N-acetyl-beta-glucosaminidase subunit beta

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight: 63

Protein Molecular Weight (kDa): 63

Storage: -20°C/1 year

Human Gene ID: 3074

Human SwissProt Number: P07686

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only