HFE2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A5348-20, A5348-100
Citations, Manuals and MSDS Available upon request.
Background: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH) . JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse, Rat
Protein Weight: 45kDa
Observed Molecular Weight: 52kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 148738
SWISS: Q6ZVN8
Alternate Names: JH; HFE2; RGMC; HFE2A
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Cell Biology Developmental Biology, Endocrine Metabolism, Neuroscience, Neurodegenerative Diseases Markers, Other Neurological disorders, Stem Cells.
NCBI Alias: HJV
Research Use Only