HIF-1β Polyclonal Antibody - RA25700

HIF-1β Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA25700-50, RA25700-100

Citations, Manuals and MSDS Available upon request.

Background: aryl hydrocarbon receptor nuclear translocator (ARNT) Homo sapiens This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013],

Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB: 1:1000-2000 IHC: 1:200-500

Alternative Names: ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta

Applications: WB; IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 405

Protein MW (KDa): 87

SWISS: P27540

Source: Rabbit

Research Use Only