HIF-1 Beta/ARNT Monoclonal Antibody (4C5) - BT-MCA0676

HIF-1 Beta/ARNT Monoclonal Antibody (4C5)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0676-20, BT-MCA0676-50, BT-MCA0676-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.

Research Areas: Epigenetics and nuclear signaling; Cardiovascular; Cancer; Metabolism

Target Protein: ARNT

Applications: WB, IHC-p, IF

Reactivity: Mouse

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Aryl hydrocarbon receptor nuclear translocator

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P27540; Mouse: P53762

Synonyms: ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta

GeneID: Human: 405

Research Use Only