HIF1 beta Monoclonal Antibody-MB12059

HIF1 beta Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB12059-50, MB12059-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P27540

Host: Rabbit

Reactivity: Human, Mouse, Rat, Hamster

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 87 kDa; Observed MW: 87 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of HIF1 beta in Raw264.7, 3T3 lysates using HIF1 beta antibody., Western blot analysis of HIF1 beta in Hela, CHO-K1, C6, Ramos lysates using HIF1 beta antibody., Immunohistochemistry analysis of paraffin-embedded Human lung cancer using HIF1 beta antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta

Immunogen: Recombinant protein of human HIF1 beta

Conjugate: Unconjugated

Modification: Unmodified