Product Description

HIKESHI Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS48446-50, BS48446-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs resμlts in inhibition of heat shock-induced nuclear accumμlation of Hsp70s, indicating a role for this gene in regμlation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, ICC/IF, IP

Alternate Names: HLD13, L7RN6, OPI10, HSPC138, HSPC179, C11orf73

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human HIKESHI

Dilution: WB: 1:1000 IHC: 1:100 ICC/IF: 1:100 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 22 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q53FT3

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only