Product Description

HINT1 (N99) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS3011-50, BS3011-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P49773

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC:1:50~1:200

Background: Hint1, or histidine triad nucleotide-binding protein 1, belongs to the first branch of the HIT superfamily. It hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Hint1 also inhibits the activity of the transcription factors AP1, MITF and USF2, as well as influences the transcription process of the Wnt/beta-catenin pathway. In addition, mammalian Hint1 has been suggested to have some tumor suppressor activity.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Hint1 (N99) pAb in paraffin-embedded human prostate cancer tissue.

Bioworld Molecular Weight: ~ 14 kDa

Specificity: Hint1 (N99) polyclonal antibody detects endogenous levels of Hint1 protein.

Alternative Name: Histidine triad nucleotide-binding protein 1; Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1; HINT1; HINT; PKCI1; PRKCNH1

Immunogen: Synthetic peptide, corresponding to amino acids 80-120 of Human Hint1.

Conjugate: Unconjugated

Modification: Unmodified