HIRA Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A12527-20, A12527-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse
Protein Weight: 112kDa
Observed Molecular Weight: 112kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 7290
SWISS: P54198
Alternate Names: TUP1; DGCR1; TUPLE1; HIRA
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Chromatin Remodeling, Cell Biology Developmental Biology, Stem Cells, Germline Stem Cells.
NCBI Alias: HIRA
Research Use Only