Histone H2A.Z (AcK11) Polyclonal Antibody-BS67177

Histone H2A.Z (AcK11) Polyclonal Antibody

Catalogue Numbers: BS67177-50, BS67177-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P0C0S5

Host: Rabbit

Reactivity: Human, Zebrafish

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 138% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Histone H2A.Z with an acetylation site at K11 protein.

Extra Notes: Western blot analysis of Histone H2A.Z (AcK11) expression in zebrafish (A) whole cell lysates.

Bioworld Molecular Weight: ~ 15 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: H2AZ; Histone H2A.Z; H2A/z

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Histone H2A.Z with an acetylation site at K11. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified