Product Description

Histone H2A.Z Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67533-50, BS67533-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Modμlation of chromatin structure plays a critical role in the regμlation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regμlating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modμlate chromatin structure . There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z . Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regμlator of transcription and is important for chromosome stability . Several homologous protein complexes, such as SWR-C (S. cerevisiae), TIP60 (D. melanogaster) and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This exchange of histone H2A variants changes histone-histone interactions in the nucleosome core and alters an acidic patch on the surface of the nucleosome, resμlting in changes in nucleosome stability and binding of non-histone proteins such as HP1α .

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Bovine, Chicken, Sheep

Host: Rabbit

Applications: WB

Alternate Names: H2AZ, Histone H2A.Z, H2A/z

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Histone H2A.Z. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Histone H2A.Z protein.

Molecular Weight: ~ 15 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P0C0S5

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only