Product Description

HIVEP3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS66125-50, BS66125-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Plays a role of transcription factor, binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobμlin and T-cell receptor gene segments, Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regμlatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regμlation promotes cell cycle progression withμltimate formation of mμltinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation, Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus, Trough non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecμle in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regμlates the expression of IL2 in T-cell. Essential regμlator of adμlt bone formation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: ELISA, IHC, IF, ICC

Alternate Names: FLJ16752, Hivep3, Human immunodeficiency virus type I enhancer-binding protein 3, Kappa-B and V(D)J recombination signal sequences-binding protein, Kappa-binding protein 1, KBP-1, KIAA1555, KRC, Schnurri-3, SHN3, Transcription factor HIVEP3, ZEP3_HUMAN, Zinc finger protein ZAS3, ZNF40C

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human HIVEP3: 1-100/2409

Dilution: ELISA: 1:5000-1:10000
IHC: 1:100-1:500
IF: 1:100-1:500
ICC: 1:100-1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: HIVEP3 Polyclonal Antibody detects endogenous levels of HIVEP3 protein.

Molecular Weight: ~ 259 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q5T1R4

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only