Product Description

HJURP Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32646-50, RA32646-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions., sequence caution:Translated as Arg., subcellular location:Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage., subunit:Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN., tissue specificity:According to PubMed:17256767 highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411 highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 82

Protein Molecular Weight (kDa): 82

Storage: -20°C/1 year

Human Gene ID: 55355

Human SwissProt Number: Q8NCD3

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only